LOS ANGELES — For DeAnn Heline, producing ABC’s “The Middle,” a situation comedy based in central Indiana, was not a huge stretch.

Born in 1965 in Muncie, Heline and her family moved to Cincinnati when she was 3, but she visited her Hoosier grandparents often.

So when Heline and her writing partner, Chicago’s Eileen Heisler, who were roommates at Indiana University, were preparing to pitch a series idea to Warner Bros., the source material was familiar.

“We began talking about a family show, because we wanted to do something for ABC, and at that time, it had really gone away from its roots, which was family comedy,” Heline said during a phone interview.

“My partner and I are both moms, tired moms. So we began talking about what it’s like to be a tired mom.”

The result was “The Middle,” about a struggling but loving family in the fictional town of Orson, Ind.

The two, who have won Humanitas Prize for their work, had experience to bring to the idea, not just from their personal lives, but also from their careers: They had been writers on the often raucous set of “Roseanne.”

“We also harkened back to those days, when we were writing about people in the middle of the country,” Heline said. “And it felt like it wasn’t that way anymore. People were setting sitcoms on the coasts, and there are so many people that we know and love, so many funny people from the Midwest.”

Heline and Heisler, who attended New York University’s Tisch School together, had experience writing for such sitcoms as “Doogie Howser, M.D.,” “Ellen,” “Murphy Brown” and “How I Met Your Mother.”

“The Middle,” though, has been their show from the ground up, with a dream cast and attributes any Hoosier would recognize, Heline added.

“I guess one of the things for us was to include the truthfulness, being very direct and very honest. I think, in L.A., people tend to say, ‘Anyone will take a meeting with you,’ even if there’s not a job. It’s all sort of B.S., you know.

“We have an episode coming up — I think it’s the first one after the pilot — in which the character says, ‘Here in the middle, people just say it as it is. There’s no B.S.’ Then we cut to the husband saying, ‘You know, you’re not fat, but that skirt sure makes you look fat.’”

The husband and wife at the center of the story are Mike and Frankie, played by Chicago’s Neil Flynn, the anonymous janitor from “Scrubs,” and Emmy Award winner Patricia Heaton (“Everybody Loves Raymond”). Their children include a teenage son named after another prominent Hoosier, rocker Axl Rose.

“We knew that Frankie would be the hardest part (to cast),” Heline said. “It was tricky, because it had to be someone who you could rest a whole show on her shoulders. And there’s really very few people who can do that.”

Heaton, a native of Ohio, was at first busy with another sitcom. When “Back to You,” which co-starred Kelsey Grammer, stalled after only a few episodes, Heaton was on board.